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Reishi mushroom (yellow lacewing, Ganoderma Lucidum) - how does it affect the human body? - Cannabinoids

Reishi mushroom (yellow lacewing, Ganoderma Lucidum) - how does it affect the human body?

The Reishi mushroom has become the subject of numerous modern scientific studies. They show that it has the potential to become the basis of antidepressant, immunomodulatory, anti-inflammatory or anti-cancer drugs. In this article, we describe the results of several studies on gybe reishi.


Reishi - the mushroom of longevity in traditional Chinese medicine (TCM)


Reishi fungus (yellow lacewing, Ganoderma Lucidum) was traditionally used in China by Taoist Buddhist monks. It was meant to support their meditation practices, cultivate inner peace, improve concentration and open the way to a long, healthy life. 


The characters that make up the Chinese name of the Reishi mushroom represent magical or divine properties, and it has sometimes been referred to as the "mushroom of immortality," "mushroom of spiritual power" and "spiritual plant." 


Reishi was listed among the highest class of tonics in the well-known Chinese medicine text, Shen Nung Ben Cao Jing (206 BC - 8 AD). Plant substances of this class were especially prized, believed to prolong life, prevent aging, strengthen chi, and make the body light and flexible. 

Reishi was said to cure feelings of tightness in the chest, strengthen the heart, nourish the center, sharpen the mind and improve memory. It was also supposed to have a beneficial effect on "virtues of character." 

Contemporary scientific research on the Reishi mushroom

According to modern scientific knowledge, gMushrooms can be used as functional foods or medicines in the prevention and treatment of several chronic diseases, as they are a rich source of bioactive metabolites. 


W research review conducted between 2015 and 2020 reads that preclinical studies have shown Reishi's pharmacological potential in diabetes, inflammation, epilepsy, neurodegeneration, cancer, anxiety, sedation, heart disease, depression, liver disease and immune disorders.

How does Reishi affect the body?


Polysaccharides in Reishi and the immune system


Yellow lacquerwort contains compounds that are widely used in medicine, nutrition, cosmetology. Of special note, according to researchers, deserve the polysaccharides (polysaccharides, complex sugars) found in Reishi, which are its most important bioactive compounds. 


According to the data collected in the study, it is the polysaccharides that are responsible for the anti-cancer, anti-inflammatory and immunomodulatory effects of Reishi. Polysaccharides from yellow lacquerwort could potentially be used to regulate the immune system.


Active polysaccharides from Ganoderma play an important role in regulating the immune response, which can include, among other things, immune defense against tumors, viruses, bacteria and fungal pathogens. It acts via lymphocytes and myeloid cells (cells with immunosuppressive effects expressed by, among other things, activating regulatory T cells, inhibiting the activity of cytotoxic T cells). 


In addition, communication between different cells of the immune system leads to enhanced production of cytokines and antibodies, even during the presence of other stimuli, such as LPS and pro-inflammatory factors.


Polysaccharides contained in Reishi and depression and anxiety


W research Reishi administration was found to produce a rapid and effective antidepressant effect in mice 60 minutes after administration. The effect persisted after 5 days of treatment with the mushroom extract. Reishi extract did not induce a hyperactive effect in the mice tested. The antidepressant effect was confirmed in a mouse model of chronic depression associated with social stress (CSDS).


The researchers suggest that the antidepressant effect was related to the action of polysaccharides contained in Reishi on specific cell-receptors Dectin-1 in the brains of mice. This study identified Reishi, which activates Dectin-1, as a potential new and rapid anti-depression drug with clinical potential and multiple beneficial mechanisms, especially in regulating the neuroimmune system.


Researchers point to the need to gather clinical data to test the safety and efficacy of specific doses of Reishi extract, which in turn would allow drug development. However, it seems that everything is ahead of us, as data on functional mushrooms is steadily increasing.


Sources:

  1. Nahata A et al, Ganoderma lucidum: A Potent Medicinal Mushroom with Numerous Health Benefits, Pharmaceut Anal Acta 2013: https://www.researchgate.net/profile/Alok-Nahata/publication/259493336_Ganoderma_lucidum_A_Potent_Medicinal_Mushroom_with_Numerous_Health_Benefits/links/00b7d52c3d2e1e8986000000/Ganoderma-lucidum-A-Potent-Medicinal-Mushroom-with-Numerous-Health-Benefits.pdf 

  2. https://onlinelibrary.wiley.com/doi/10.1002/ptr.7215 

  3. Haoran L et al, Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system, Brain Research Bulletin, 2021: https://www.sciencedirect.com/science/article/abs/pii/S0361923021000721 

  4. Ren L et al, Immunomodulatory activities of polysaccharides from Ganoderma On immune effector cells, Brain Research Bulletin, 2021: https://www.sciencedirect.com/science/article/abs/pii/S0308814620317957 

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