The entourage effect, i.e. the mutual complementation of compounds contained in hemp, is a frequently used argument for the use of full spectrum preparations. The benefits of this synergy are well described, the author of this concept is Raphael Mechoulam himself. It is also worth paying attention to the specific combination of CBD, CBG and THC cannabinoids, which is the subject of a growing number of studies. Selected ones are described below.
What is CBG?
CBG (cannabigerol) is one of the hemp cannabinoids, just like CBD and THC, it is produced by plants from the Cannabis family and has the ability to bind to the receptors of the endocannabinoid system in the human body (and other mammals). Even though it was isolated in 1964, broader research on its properties began only a few years ago.
CBG – “mother of cannabinoids”
CBG in its acid form, or CBGA, is the precursor to most cannabinoids. As the cannabis plant grows, CBGA branches into three main cannabinoids: CBDA, or cannabidiolic acid, CBCA, or cannabichromenic acid, and THCA, or tetrahydrocannabinolic acid.
Under the influence of temperature, the acidic forms of cannabinoids are transformed into better known forms and this form activates the CB1 and CB2 receptors in our body. That is why CBG is sometimes called the "mother of cannabinoids".
CBG itself is also a "full cannabinoid" that has specific properties: it has analgesic and anti-inflammatory properties, balances hormonal balance, and regulates appetite.
CBD, CBG, THC – the benefits of the combination
Research shows that when CBD is combined with THC , CBG and other cannabinoids, it can provide more therapeutic benefits. This relationship is called the "entourage effect". This concept was presented by Professor Raphael Mechoulam. The researcher found that cannabinoids work best when administered together, then they complement each other and bring out the best in each other.
CBG can, for example, eliminate the side effects of the psychoactive effect of THC, while enhancing its positive properties , e.g. antiemetic, anticonvulsant, anti-inflammatory and analgesic effects.
CBD, CBG and THC – how do they affect the body when administered together? Selected scientific research.
The combination of CBD and CBG deserves special attention Let's take a look at the scientific research that has focused on the possible uses of these cannabinoids in various situations.
- According to the authors of an article published in 2023, there is an unmet need for painkillers that effectively relieve pain after a fracture. This demand, due to their mechanism of action and side effects, is not met by non-steroidal anti-inflammatory drugs (they hinder healing - they inhibit the "needed" inflammation) and opioids (they are highly addictive).
Researchers examined the analgesic effectiveness of two cannabinoids, CBD and CBG, in a mouse model of tibial fracture. Both CBD and CBG normalized pain sensitivity to all tested stimuli, and their analgesic effect was comparable to that of NSAIDs. At the same time, CBD and CBG promoted bone healing in all healing phases. Data collected in the study suggest that CBD and CBG are therapeutic agents that can replace NSAIDs in the treatment of post-traumatic pain .
- Scientists have shown that higher concentrations of CBD and CGB in dried medical hemp may increase the effectiveness and tolerance of THC in patients who respond less well to treatment with preparations containing the psychoactive cannabinoid.
- According to research results, CBD and CBG have the ability to prevent the abnormal cell growth and multiplication that occurs in cancer. Although more research is needed, the results of existing research are promising.
- Other studies have shown that both CBD and CBG have antispasmodic properties, which means they can help alleviate or eliminate epileptic seizures.
- ability to relieve pain is well known, as are its many side effects, including: somnolence. One study analyzed the ability of THC, CBD and CBG, used individually and in combination, to block pain responses. Cannabinoids were tested on sensory neurons grown in the laboratory (tissue cultures) that respond to pain stimuli, such as the compound responsible for the spiciness of chili peppers - capsaicin.
It was shown that THC, CBG and CBD used individually were able to block capsaicin responses in sensory neurons, but THC, CBD and CBG combined in a 1:1:1 ratio were more effective. This combination also increased the effectiveness of THC at a lower dose, which may make it possible to reduce the concentration of the psychoactive cannabinoid in the medicinal herb. The results of this study pave the way for clinical trials to develop more effective cannabis-based painkillers .
We encourage you to read the article in which we describe new research results on the mechanism of action of CBD in inflammation .
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